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Purified silk fibers, an inert carrier,
provides ENHANCED:
  • Cohesion
  • Mechanical Properties
  • Handling Characteristics
This enables i-FACTOR Flex FR to provide significant
new application options while retaining the safety
and efficacy of P15 technology.

i-FACTOR Flex FR, with
purified silk, retains the
safety and
P-15 technology while
providing superior out
of package handling
and in-vivo cohesive


  1. Yang XB, Bhatnagar RS, Li S, Oreffo RO. Biomimetic collagen scaffolds for human bone cell growth and differentiation. Tissue Eng. 2004 Jul-Aug;10(7-8):1148-59.
  2. Biomaterials. Apr 2009; 30(10): 1898-1909. The effect of collagen I mimetic peptides on mesenchymal stem cell adhesion and differentiation, and on bone formation at hydroxyapatite surfaces KM Hennessy, BE Pollot, WC Clem, MC Phipps, AA Sawyer, K Culpepper, and SL Bellis*
  3. Design of Biomimetic Habitats for Tissue Engineering with P-15, a Synthetic Peptide Analogue of Collagen Rajendra S. Bhatnagar, Jing Jing Qian, Anna Wedrychowska, Mahyar Sadeghi, Yi Min Wu, and Nancy Smith. Tissue Engineering. February 1999, 5(1): 53-65. doi:10.1089/ten.1999.5.53. Volume: 5 Issue 1: January 16, 20
  4. Yukna RA, Callan DP, Krauser JT, Evans GH, Aichelmann-Reidy ME, Moore K, Cruz R, Scott JB. Multi-center clinical evaluation of combination anorganic bovine-derived hydroxyapatite matrix (ABM)/cell binding peptide (P-15) as a bone replacement graft material in human periodontal osseous defects. 6- month results. J Periodontol. 1998 Jun;69(6):655-63.
  5. Int Orthop. Feb 2007; 31(1): 93-99. P-15 small peptide bone graft substitute in the treatment of non-unions and delayed union. A pilot clinical trial. Francisco Gomar, Rafael Orozco, Jose Luis Villar, and Federico Arrizabalaga
  6. Silk-based biomaterials. Altman, Gregory, H.; Diaz, Frank; Jakuba, Caroline; Calabro, Tara; Horan, Rebecca, L.; Chen, Jingsong; Lu, Helen; Richmond, John; Kaplan, David, L.[author, Reprint-Author], 2003: Silk-based biomaterials. Biomaterials 24(3): 401-416. Graphic used by permission.