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Safe. Natural. Predictable.

i-FACTOR™ is the only Biologic Bone Graft that uses a unique small peptide (P-15™) to safely and naturally stimulate the bone healing process. This novel mechanism of action results in predictable bone formation, minimizing the safety issues associated with growth factors.

 

SAFE

  • i-FACTOR Biologic Bone Graft enables surgeons to avoid the morbidity of harvesting autograft.

NATURAL

  • i-FACTOR targets specific integrins in osteogenic cells to stimulate the natural bone healing process.

PREDICTABLE

  • Unlike growth factor products, i-FACTOR only stimulates bone growth in the presence of bone forming cells, decreasing the likelihood of ectopic bone formation.

PROVEN

  • i-FACTOR has been used in more than 2,000 spine and trauma surgeries worldwide.
  • i-FACTOR demonstrates efficacy equivalent to autograft.1
  • PMA approved as a bone graft substitute for dental indications, with study outcomes proving clinical superiority to both alloplasts and allografts (DBM).2

EASY TO USE

  • i-FACTOR bone graft is easy to use in a wide range of orthopedic and spine procedures.
  • Two product forms (Putty and Flex) allow clinicians to choose the handling characteristics best suited to specific applications.

1 Evaluation of ABM/P-15 versus autogenous bone in an ovine lumbar fusion model.
Blake P. Sherma, Emily M. Lindley, A. Simon Turner, Howard B. Seim III, James Benedict, Evalina L. Burger, Vikas V. Patel; European Spine Journal; DOI 10.1007/s00586-010-1546-z.

P15™ Small Peptide Bone Graft Substitute in the Treatment of Non-Unions - A Pilot Clinical Trial.
F. Gomar, R. Orozco, J.L. Villar, and F. Arrizabalaga; International Orthopedics June 2006.

2 Multi-center clinical evaluation of combination anorganic bovine bone-derived hydroxyapatite matrix (ABM)/cell-binding peptide (P-15) and ABM in human periodontal osseous defects: 6-month results. Yukna RA, Callan DP, Krauser JT, et al. Journal of Periodontology 1998; 69:655-663.

Multi-center clinical comparison of combination anorganic bovine bone-derived hydroxyapatite matrix (ABM)/cell-binding peptide (P-15) and ABM in human periodontal osseous defects: 6-month results. Yukna RA, Callan DP, Krauser JT, et al. Journal of Periodontology 2000; 71:1671-79.